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Lee Machado

Lee is a Senior Lecturer in Biochemistry in the School of Health, co-leader of the Ageing Research Centre (ARC) in the Institute of Health and Wellbeing at the University of Northampton and Honorary Fellow in the Department of Genetics at the University of Leicester.

Lee completed an undergraduate degree at the University of Warwick and a PhD in cancer studies at the University of Birmingham. He conducted postdoctoral research at the Institute for Cancer Studies (Birmingham), the MRC toxicology unit (Leicester) and the Department of Genetics (Leicester) before working as a senior scientist for the cancer vaccine company, Scancell (Nottingham); Lee came to the University of Northampton as a Lecturer in 2013.

Lee’s research is focused on employing cellular and molecular genetic strategies to address how the host immune system responds to pathogens and cancer. The aim of this work is to increase our understanding of human health and disease and develop rational therapeutic approaches to harness the exquisite specificity and sensitivity of the immune system. Key areas of research are:

  • Copy number variation of immunity genes
  • Tumour immunology and the development of cancer immunotherapy

Lee collaborates locally, nationally and internationally to advance his research agenda and has worked on Cancer Research UK, Medical Research Council and Wellcome Trust funded projects. He is a regular reviewer for a number of academic journals including Human Immunology, Blood and PLOSone. He has published in high impact journals including Blood, American Journal of Human Genetics and the American Journal of Pathology and is an occasional reviewer for major funding bodies.